People & Culture

Given a rare room
to grow.

Director of HR Operations · People Strategist · SPHR Candidate

Most HR professionals spend the better part of a decade before they touch every part of the function. I'm grateful to have been given that room in half that time, inside the kind of fast-paced biotech environment where I had to own payroll, compliance, benefits, talent acquisition, and culture end-to-end — and where I also got to help lead a reverse merger acquisition and build organizational design and culture from the ground up. It's a training ground I don't take for granted.

Catherine Vesey
15+
Years of professional operations & HR leadership
4+
Years full-spectrum HR ownership
SPHR
Candidate — exam September 10, 2026
Local
Relocating to Charleston, SC

My Approach

What makes my HR
experience different.

Most HR professionals have a lane. A specialty. A function they're known for. I was given something different: a training ground. Our CPO had a distinct mandate from the board — to formalize culture and people operations and get a pre-commercial biotech company commercial-ready — and it was just the two of us to do it. I set out to serve her goal: owning and performing every HR role myself while partnering with her on strategy, so every process, system, and communication we built stood in service of that mandate. That's who I've been across every role since — someone who shows up for the goal in front of her and the people working toward it, and grows into whatever the work asks of her next. People didn't hand me more responsibility because I asked for it. They handed it to me because I'd shown up enough times, in the right way, that they trusted me with it. I don't take that lightly.

Trusted in hard moments

When Selecta needed to reduce its workforce across six structured RIFs, I wasn't briefed afterward — I was in the room, delivering the news directly to impacted employees with care and dignity. I built the separation packages, engaged outplacement services, and organized a Lunch & Learn on job searching for departing employees. When it was over, people felt taken care of. That's the part I was proudest of.

Handed the whole function

Not just programs — the underlying machinery, one piece at a time, as I was given more to hold. I processed payroll, administered the 401(k) plan, managed benefits negotiations and renewals, ran FMLA, handled separations, and recruited end-to-end including background checks, I-9s, and E-Verify. Most recently I restructured a full manufacturing operation to support 7-day production — redesigning the org, hiring the staff, and building the shift framework in both HRIS and payroll from scratch. People trusted me with more each time, because I'd handled the last piece with care.

Resourceful in service of the team

When we didn't have the budget to buy a new all-in-one HR platform, I identified that iSolved — the system we already had — could be expanded to cover HRIS, ATS, performance management, and learning, all for less per user than what we were paying across fragmented tools. I built the case, got stakeholder buy-in, and managed the vendor relationship that made it possible — because protecting the team's time and the company's resources felt like part of the job.

Experience

Where I've operated,
built, and delivered.

Feb 2025 — Oct 2025

Director, Head of HR Operations

Cartesian Therapeutics · Remote

The CEO asked me back to restore payroll and HRIS compliance after a reportable payroll error and a SEC/SOX compliance issue — serious enough that they needed someone who could remedy it quickly and cleanly. That call was a measure of the trust I'd built the first time around. I restored People Operations to full compliance and operational excellence, led the full manufacturing operations restructuring to enable 7-day production — redesigning the team structure, running end-to-end recruitment for new manufacturing shifts, and building the shift work framework in both HRIS and payroll from the ground up. Rebuilt the HRIS to full SEC/SOX compliance standards across 60+ employee records, and reduced benefits renewal cost growth from a projected 13%+ down to 3% through broker negotiations and market analysis. Led the annual compensation cycle with AON Radford and re-launched the unlimited PTO policy with clear approval and reporting standards.

Manufacturing HRPayroll ComplianceSEC/SOX RemediationBenefits NegotiationCompensation (AON Radford)HCM / LMSMulti-State Compliance

Nov 2023 — July 2024

Assistant Director, Head of HR Operations

Cartesian Therapeutics · Remote

Continued as the sole HR operator following Selecta's acquisition and transition to Cartesian Therapeutics. Owned all HR operations including payroll administration, benefits open enrollment and renewals, 401(k) plan administration (Fidelity), FMLA management, policy development, and employee communications. Ran talent acquisition from job posting through offer, background checks, I-9 verification, and E-Verify — ensuring full onboarding compliance for every new hire. Supervised a TA contractor and served as the primary point of contact for candidates and hiring managers throughout the full recruitment cycle. Authored the company's Flexible Vacation Policy, T&E Policy, Parental Leave Policy, and time-tracking rollout. Built and pitched the business case to centralize HR operations into a unified HCM platform using existing iSolved infrastructure — a cost-saving solution that avoided purchasing new software.

PayrollFull-Cycle RecruitingI-9 / E-Verify / BGC401(k) AdministrationBenefits & Open EnrollmentFMLAPolicy AuthoringHCM Strategy

Apr 2021 — July 2024

Manager, People and Culture → Assistant Director, HR Operations

Selecta Biosciences · Watertown, MA

Held concurrently with a separate Executive Administration & Operations role for one year (2021–2022) during the formal transition into HR leadership.

Joined as part of a small HR team and was given room to grow into the operational core of the function, supporting the Chief People Officer across the full employee lifecycle — from sourcing and recruiting through offer, background checks, I-9 and E-Verify compliance, and onboarding, all the way through offboarding and separation. Ran talent acquisition end-to-end, coordinating with hiring managers, managing candidate pipelines in iSolved ATS, and ensuring every new hire arrived fully compliant and prepared. Co-led the company's Culture Ambassador program and the all-company annual kick-off meeting. When the company conducted a targeted workforce reduction, built all separation packages, engaged outplacement services, organized a Lunch & Learn for departing employees covering job searching and resume writing, and coordinated 16 exit discussions on a single day. Built and managed the co-op program, including cross-functional shadowing, cohort interviews, and hiring manager roadmaps.

Full-Cycle RecruitingOnboarding & ComplianceI-9 / E-VerifyBackground ChecksTotal RewardsBenefits AdministrationRIF & SeparationsCulture Programs

2005 — 2021

Executive Operations & C-Suite Partnership

Selecta Biosciences · Cerulean Pharma · Public Preparatory Network · and others

Before transitioning formally into HR, I spent over a decade as a C-Suite executive assistant and operational partner at venture-backed biotech companies and mission-driven nonprofits — supporting CEOs, CMOs, CFOs, and boards at organizations including Selecta Biosciences and Cerulean Pharma.

At that level, the work was always more than logistics. I coordinated IPO Test-the-Waters roadshows and investor meetings. I managed board communications, drafted board correspondence, and built a perpetual board prep calendar that raised director satisfaction by 85%. I ran investor relations — maintaining the CRM database, preparing backgrounders, and organizing Investor Cocktail Receptions during ASCO. I project managed three company website redesigns and owned the IR webpage. I implemented enterprise software company-wide — sourcing vendors, running RFPs, and training the full organization on adoption. I stepped into a Clinical Operations Associate role mid-tenure at Cerulean when the CMO needed someone he trusted to restructure his office — a level of trust I didn't take lightly.

The organizational precision, stakeholder instincts, and C-Suite partnership I developed during those years are woven into everything I do in HR today. When I know how executives think, what boards need before they ask, and what a seat at the table actually requires — that shapes every people decision I make.

CEO & CMO SupportBoard ManagementInvestor RelationsIPO RoadshowsExecutive CommunicationsProject ManagementEnterprise Software RolloutOperations

Work Samples

A closer look
at the work.

Everything below is something I conceived, designed, executed, or owned end-to-end. Going by a traditional HR org chart, this was several jobs — but at Selecta and Cartesian, it was one role, and it turned out to be the best leadership training ground I could have asked for. Samples available upon request.

Total Rewards · Benefits & 401(k)

Benefits Administration & 401(k) Oversight

Owned benefits open enrollment and renewals end-to-end — coordinating with brokers and carriers, communicating options to employees, and managing all enrollment data. Served as the 401(k) Plan Administrator for the company's Fidelity retirement plan, which included executing plan document amendments, managing the ADP-to-Fidelity transition, conducting employee information sessions on plan mechanics and account setup, and ensuring DOL compliance.

Coordinated 401(k) information sessions for the full employee population post-acquisition, organized equity grant distribution and E*Trade activation, and executed plan document amendments with Fidelity directly.

Leave Management · Compliance

FMLA & Parental Leave Administration

Managed FMLA administration from initial request through return-to-work certification, including coordinating concurrent STD and parental leave, tracking eligibility, requiring medical documentation, and advising managers throughout the process. Authored Cartesian's complete Parental Leave Policy and Manager Guide — covering paid leave entitlements, FMLA interplay, pay and benefits continuity, and a six-step framework for managers on handling parental leave with empathy and compliance.

Policy and manager guide completed April 2025; covers 12 weeks paid parental leave at 100% wages, FMLA eligibility, documentation process, and manager preparation steps from planning through return.

Manufacturing HR · Workforce Restructuring

7-Day Manufacturing Shift Buildout

When Cartesian needed to expand to 7-day manufacturing production, I led the full HR side of that buildout — redesigning the team structure and org chart in partnership with Manufacturing leadership, running end-to-end recruitment to hire the additional staff needed for new shifts, and building the shift work framework from scratch in both the HRIS and payroll systems to ensure accurate scheduling, compliance, and compensation processing across all shifts. Delivered expanded capacity without disrupting existing operations or team continuity.

New shift structure operational with compliant HRIS and payroll setup — all hiring, onboarding, and compensation frameworks delivered without production disruption.

Compliance · Payroll · Benefits

Compliance Remediation & Cost Recovery

Brought back to Cartesian specifically to restore a People Operations function following a high-stakes compliance failure. Remediated an SEC-reportable payroll violation and rebuilt the HRIS to full SEC/SOX compliance standards — correcting data accuracy across 60+ employee records with speed and precision that rebuilt trust across Finance, Legal, and the executive team. Simultaneously renegotiated the benefits renewal, reducing projected cost growth from 13%+ down to 3% through broker negotiations and market analysis.

SEC-reportable violation remediated. HRIS rebuilt to SOX compliance. Benefits cost growth cut by 10 percentage points — protecting significant projected spend for plan year 2026.

Crisis Operations · Workforce Reduction

RIF Execution — End to End

When Selecta conducted a targeted workforce reduction, I was the HR person in the room — delivering the news to impacted employees directly, alongside their executive team member. Before that day, I built every separation package, engaged outplacement services, organized a Lunch & Learn on resume writing and job searching for departing employees, drafted manager FAQs, and coordinated 16 exit discussions across a two-hour window. After, I stabilized communications for retained employees. The people who left were treated with dignity. The people who stayed had clarity.

"Catherine will put these invites on your calendars accordingly." — CPO Kristen Baldwin, in materials sent to Selecta's Executive Team the morning of the RIF

Systems Strategy · Cost Management

HR Systems Centralization — No New Budget

Identified that employees were navigating four separate HR platforms, creating friction and administrative burden. Rather than proposing new software, I recognized that iSolved — the system already in place — could be expanded to cover the full employee lifecycle at lower per-user cost than the fragmented status quo. I built the business case from scratch, ran the cost comparison, presented it to leadership, and managed the vendor relationship with iSolved that made expansion possible.

Proposed consolidating from $7/user/mo (fragmented tools) to $6/user/mo (unified HCM), saving money while improving employee experience — by using what we already had, creatively.

Policy Design · Compliance

Policy Suite: Authored from Scratch

Wrote the policies that governed how Cartesian's employees worked — not revised templates from counsel, but substantive, employee-facing documents I authored and owned. Included: the Flexible Vacation Policy (with manager and employee guidance, blackout period rules, and abuse frameworks), the Parental Leave Policy and Manager Guide, the Travel & Expense Policy Guidebook, the Tuition Reimbursement Program, and the Time Reporting and iSolved implementation policy for multi-state and NIH grant compliance.

Policies ranged from operationally complex (multi-state sick time compliance, NIH grant time tracking) to culture-forward (flexible vacation with no accrual cap, parental leave at 100% wages for 12 weeks).

Culture · Performance · Employee Experience

Culture & Performance Programs

Co-ran the Culture Ambassador program across four workstreams at Selecta — including launching the company's first annual Pioneer of the Year recognition award at the all-company kick-off meeting. At Cartesian, designed and delivered the company-wide performance management rollout, introducing a quarterly check-in cycle through Small Improvements and coaching managers through the process. Also authored the company's integration communications newsletter (INFORM) during the post-acquisition period, coordinating equity sessions, 401(k) onboarding, and IT office hours.

Performance management launched Feb 2024 across the full organization; culture ambassador program ran for the full 2022–2023 calendar year with structured roadmaps and four active workstreams.

Employer Brand · Creative Direction

Employee Spotlight & Brand Rehaul

Conceptualized and produced an employee spotlight video series in partnership with the external creative firm I hired to lead Selecta's brand and website rehaul. I identified the need, sourced and selected the vendor, directed the creative brief, and shepherded the project from concept through final production — giving the organization a visual identity and narrative that could attract talent and reflect the culture we were building.

One of several deliverables from a full brand and website refresh I led. The spotlight series brought employee voices to the forefront as a recruitment and culture tool.

In Their Words

From the people who
have seen me work.

"

Catherine was my right hand in all aspects of HR. She held broad responsibilities, including recruitment, benefits, development and culture initiatives, diversity and inclusivity, and HR data and information technology. She possesses an exceptionally high capacity and brings integrity to her work.

Kristen BaldwinChief People Officer, Selecta Biosciences · Direct Manager
"

She ran the day-to-day operations of HR completely independently. Catherine has a good working knowledge of all of the key functional areas of HR and knows how to leverage the resources she has to get things done. She is very diligent, tech savvy and thoughtful — a great mix of all the things you want in an HR professional.

Jessica Wagner Keliher, SPHRChief Human Resources Officer, Cartesian Therapeutics · Direct Manager
"

Catherine is one of the best I have ever seen at figuring out how to get things done efficiently and at speed. I would recommend her to anyone looking to hire her in just about any field, regardless of whether she has prior experience.

Matthew BartholomaeGeneral Counsel & Secretary, Cartesian Therapeutics
"

She is positive and motivated with a get-it-done attitude, but moreover brings a level of strategic partnership to ensure that her business partners are always ahead of the game, whether they be C-level executives, HR leaders, or otherwise.

Brad DahmsChief Financial Officer, Jade Biosciences · Direct Manager

Capabilities

The full spectrum
of what I bring.

Operations & Compliance

  • Payroll Administration
  • Benefits Administration & Open Enrollment
  • 401(k) Plan Administration
  • FMLA & Leave Management
  • I-9 / E-Verify / Background Checks
  • HRIS & ATS Administration (iSolved)
  • Multi-State Compliance
  • Policy Authoring & Rollout

Talent & Culture

  • Full-Cycle Talent Acquisition
  • Onboarding Compliance & Offboarding
  • Performance Management
  • Learning & Development
  • Culture Programs & Recognition
  • Employee Communications
  • DEI Initiatives

High-Stakes & Strategic

  • Manufacturing HR & Shift Buildout
  • Payroll & SEC/SOX Compliance
  • Benefits Negotiation & Renewal
  • Compensation Strategy (AON Radford)
  • RIF Execution & Separations
  • M&A HR Integration
  • Executive-Level Partnership

Beyond Work

A life of gratitude.

Italy keeps pulling me back — specifically the parts that are hard to get to, where the effort of getting there makes everything that follows feel more real. Climbing there, not knowing what's at the top or if I'll even make it, has become a physical embodiment of my faith — a daily walk that asks me to keep climbing especially when I can't see the peak, and the overwhelming rush of emotions when met with all the beauty along the way that cannot even be imagined.

"I press on toward the goal for the prize of the upward call of God in Christ Jesus." — Philippians 3:14

Cala Goloritzé · Sardinia  ·  Marettimo · Sicily  ·  Rome  ·  photography

Hiking the cliffs above Marettimo at dawn, Sicily Appian Way · Rome
Biking the Appian Way, Rome Marettimo, Sicily — dawn hike
Caravaggio's Judith Beheading Holofernes, Rome Rock arch trail · Sardinia
Cala Goloritzé, Sardinia Sea cave · Marettimo
Rock arch hiking trail, Sardinia Cala Goloritzé · Sardinia

Let's talk about
what you're building.

Whether you're standing up a new HR function, navigating a complex people challenge, or looking for an operator who can think and execute across the full spectrum — I'd love to hear what you're working on.

In addition to HR Operations leadership, I'm open to senior Executive Assistant, Chief of Staff, and Executive Operations roles where the scope calls for the same level of precision, trust, and C-Suite partnership.